(3,5-Dimethoxyphenyl)acetic acid → HCID 70975957, compound

HRID 535594Notes

Reaction equation

HRID 535594 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:29][C:30](O)=[O:31])[CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1>>[CH3:28][O:27][C:25]1[CH:24]=[C:23]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:31])[CH:22]=[C:21]([O:20][CH3:19])[CH:26]=1

Participants

3

Reactant 2

HCID 138316(3,5-Dimethoxyphenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975957HCID 70975957, compound

Procedure

The product of Example 1B and 2-(3,5-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=1.3 Hz, 1H), 7.97-8.01 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 6.58 (d, J=2.3 Hz, 2H), 6.41 (t, J=2.3 Hz, 1H), 3.80-3.84 (m, 4H), 3.76 (s, 6H), 3.59 (s, 2H), 3.08-3.11 (m, 4H); MS (ESI−) M/Z 423 (M−H)−.

Sources & evidence

ORD record
ord-ac7bf3f9ea3641a9b2ca750c35d325ba
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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