2,5-Difluorophenylacetic acid → HCID 70975857, compound

HRID 535597Notes

Reaction equation

HRID 535597 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=1[CH2:27][C:28](O)=[O:29]>>[F:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=1[CH2:27][C:28]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:29]

Participants

3

Reactant 2

HCID 5228232,5-Difluorophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975857HCID 70975857, compound

Procedure

The product of Example 1B and 2-(2,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.32 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.90-7.93 (m, 1H), 7.36 (ddd, J=9.0, 5.8, 3.2 Hz, 1H), 7.12-7.29 (m, 2H), 3.82-3.84 (m, 4H), 3.75 (s, 2H), 3.09-3.11 (m, 4H); MS (ESI+) M/Z 401 (M+H)+.

Sources & evidence

ORD record
ord-095149eaffce48209fb093e0f24b8b19
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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