3,4-Dichlorophenylacetic acid → HCID 70975877, compound

HRID 535598Notes

Reaction equation

HRID 535598 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Cl:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](O)=[O:29])[CH:23]=[CH:24][C:25]=1[Cl:26]>>[Cl:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:29])[CH:23]=[CH:24][C:25]=1[Cl:26]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975877HCID 70975877, compound

Procedure

The product of Example 1B and 2-(3,4-dichlorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.66 (d, J=2.0 Hz, 1H), 7.63 (d, J=8.2 Hz, 1H), 7.37 (dd, J=8.2, 2.1 Hz, 1H), 3.80-3.84 (m, 4H), 3.72 (s, 2H), 3.08-3.11 (m, 4H); MS (ESI−) M/Z 431 (M−H)−.

Sources & evidence

ORD record
ord-189ca883736648d88b4f147434b62356
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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