4-Mesylphenylacetic acid → HCID 70975807, compound

HRID 535600Notes

Reaction equation

HRID 535600 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31](O)=[O:32])=[CH:26][CH:25]=1)(=[O:23])=[O:22]>>[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([NH:1][N:2]2[N:11]=[C:10]([S:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:32])=[CH:26][CH:25]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 5723454-Mesylphenylacetic acidHCID 70976345HCID 70976345, compound

Product 1

HCID 70975807HCID 70975807, compound

Procedure

The product from Example 57B and 2-(4-(methylsulfonyl)phenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ 11.78 (s, 1H), 8.34 (dd, J=7.9, 1.1, 1H), 8.08 (d, J=7.7, 1H), 8.03-7.97 (m, 1H), 7.97-7.92 (m, 1H), 7.92-7.87 (m, 2H), 7.60 (d, J=8.3, 2H), 7.45-7.40 (m, 2H), 7.40-7.30 (m, 3H), 3.81 (s, 2H), 3.22 (s, 3H); MS (APCI+) M/Z 466 (M+H)+.

Sources & evidence

ORD record
ord-5ea4ebef675d49fea04bf3d542a39681
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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