4-Mesylphenylacetic acid → HCID 70975944, compound

HRID 535605Notes

Reaction equation

[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[CH3:22][S:23]([C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33](O)=[O:34])=[CH:28][CH:27]=1)(=[O:25])=[O:24]>>[CH3:22][S:23]([C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33]([NH:1][N:2]2[N:11]=[C:10]([S:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)(=[O:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:34])=[CH:28][CH:27]=1)(=[O:24])=[O:25]

Participants

Reactant 2

HCID 5723454-Mesylphenylacetic acid

HCID 70975871HCID 70975871, compound

Product 1

HCID 70975944HCID 70975944, compound

Procedure

The product from Example 68B and 2-(4-(methylsulfonyl)phenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ 11.97 (s, 1H), 8.56 (d, J=8.2, 1H), 8.42-8.35 (m, 1H), 8.15-8.08 (m, 1H), 8.04-7.99 (m, 3H), 7.91 (d, J=8.3, 2H), 7.82-7.77 (m, 1H), 7.71-7.65 (m, 2H), 7.57 (d, J=8.3, 2H), 3.83 (s, 2H), 3.24 (s, 3H); MS (DCI+) M/Z 515 (M+NH4)+.

Sources & evidence

ORD record: ord-a3f2f195ffe54739977e0bb87889c3c6
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859549B2

Reaction notes

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