4-Chlorophenylacetyl chloride → HCID 70976215, compound

HRID 535612Notes

Reaction equation

HRID 535612 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](Cl)=[O:30])=[CH:24][CH:23]=1>>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([S:12][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:20])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:25]3[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][CH:24]=3)[N:11]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975848HCID 70975848, compound

Product 1

HCID 70976215HCID 70976215, compound

Procedure

The product from Example 195B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ 11.70 (s, 1H), 8.34 (d, J=7.1, 1H), 8.08-8.03 (m, 1H), 8.03-7.98 (m, 1H), 7.97-7.92 (m, 1H), 7.56 (d, J=8.6, 2H), 7.44-7.36 (m, 4H), 7.35-7.31 (m, 2H), 3.67 (s, 2H); MS (DCI+) M/Z 519 (M+NH4)+.

Sources & evidence

ORD record
ord-aabca02d99a242b5bedf01cd6ff1c8cc
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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