3-(Trifluoromethyl)benzeneacetic acid → HCID 70975994, compound

HRID 535620Notes

Reaction equation

HRID 535620 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[F:22][C:23]([F:35])([F:34])[C:24]1[CH:25]=[C:26]([CH2:30][C:31](O)=[O:32])[CH:27]=[CH:28][CH:29]=1>>[O:21]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([S:12]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:13])=[N:11][N:2]1[NH:1][C:31](=[O:32])[CH2:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([C:23]([F:34])([F:22])[F:35])[CH:25]=1

Participants

3

Reactant 2

HCID 676953-(Trifluoromethyl)benzeneacetic acidHCID 70975871HCID 70975871, compound

Product 1

HCID 70975994HCID 70975994, compound

Procedure

The product from Example 68B and 2-(3-(trifluoromethyl)phenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.93-11.95 (bs, 1H), 8.55-8.57 (m, 1H), 8.37-8.40 (m, 1H), 8.09-8.13 (m, 1H), 7.98-8.03 (m, 3H), 7.77-7.82 (m, 1H), 7.59-7.71 (m, 6H), 3.83 (s, 2H); MS (ESI−) M/Z 486 (M−H)−.

Sources & evidence

ORD record
ord-9e5fafd4811c4edcb276bf9f550a8beb
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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