3,5-Difluorophenylacetic acid → HCID 70975777, compound

HRID 535625Notes

Reaction equation

HRID 535625 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](O)=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[CH2:13]([S:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:20])[N:2]([NH:1][C:30](=[O:31])[CH2:29][C:24]2[CH:23]=[C:22]([F:21])[CH:27]=[C:26]([F:28])[CH:25]=2)[N:11]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 70976123HCID 70976123, compound

Product 1

HCID 70975777HCID 70975777, compound

Procedure

The product from Example 212B and (3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.75 (s, 1H), 8.32-8.35 (m, 1H), 7.91-8.02 (m, 3H), 7.39-7.41 (m, 2H), 7.24-7.27 (m, 3H), 7.14-7.18 (m, 3H), 4.34 (s, 2H), 3.79 (s, 2H); MS (DCI+) M/Z 455 (M+NH4)+.

Sources & evidence

ORD record
ord-67723092555e46f19e15507bc65a5969
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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