4-Chlorophenylacetyl chloride → HCID 70976214, compound

HRID 535626Notes

Reaction equation

HRID 535626 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](Cl)=[O:30])=[CH:24][CH:23]=1>>[CH2:13]([S:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:20])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:25]2[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][CH:24]=2)[N:11]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70976123HCID 70976123, compound

Product 1

HCID 70976214HCID 70976214, compound

Procedure

The product from Example 212B and (4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.69 (s, 1H), 8.32 (dd, J=8.1, 1.3 Hz, 1H), 7.90-8.01 (m, 3H), 7.37-7.43 (m, 6H), 7.23-7.26 (m, 3H), 4.32 (s, 2H), 3.72 (s, 2H); MS (DCI+) M/Z 453 (M+NH4)+.

Sources & evidence

ORD record
ord-2958835e6f724a7fb0168d3df8f57e91
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

Loading…