4-Fluorophenylacetyl chloride → HCID 70975868, compound

HRID 535629Notes

Reaction equation

HRID 535629 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:23].[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32](Cl)=[O:33])=[CH:27][CH:26]=1>>[C:21]([C:18]1[CH:19]=[CH:20][C:15]([S:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:23])[N:2]([NH:1][C:32](=[O:33])[CH2:31][C:28]3[CH:29]=[CH:30][C:25]([F:24])=[CH:26][CH:27]=3)[N:11]=2)(=[O:14])=[O:13])=[CH:16][CH:17]=1)#[N:22]

Participants

3

Reactant 2

HCID 37449884-Fluorophenylacetyl chlorideHCID 70976118HCID 70976118, compound

Product 1

HCID 70975868HCID 70975868, compound

Procedure

The product from Example 224A and 2-(4-fluorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.86-11.86 (m, 1H), 8.53 (d, J=8.1 Hz, 1H), 8.31-8.47 (m, 1H), 8.14-8.20 (m, 4H), 8.09-8.16 (m, 1H), 7.99-8.07 (m, 1H), 7.28-7.34 (m, 2H), 7.14-7.20 (m, 2H), 3.66 (s, 2H); MS (ESI−) M/Z 461 (M−H)−.

Sources & evidence

ORD record
ord-e4955625d6064872bb9e1e409f5f6611
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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