4-Fluorophenylacetyl chloride → N-{4-[(4-cyanophenyl)sulfonyl]-1-oxophthalazin-2(1H)-yl}-2-(4-fluorophenyl)acetamide

Participants

Reaction Steps

The product from Example 224A and 2-(4-fluorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.86-11.86 (m, 1H), 8.53 (d, J=8.1 Hz, 1H), 8.31-8.47 (m, 1H), 8.14-8.20 (m, 4H), 8.09-8.16 (m, 1H), 7.99-8.07 (m, 1H), 7.28-7.34 (m, 2H), 7.14-7.20 (m, 2H), 3.66 (s, 2H); MS (ESI−) M/Z 461 (M−H)−.

Provenance & Evidence