Pyrrolidine → HCID 59636780, compound

HRID 535647Notes

Reaction equation

HRID 535647 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([O-:26])=O)=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[Li+].[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[O:26])=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68787401Lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate

Product 1

HCID 59636780HCID 59636780, compound

Procedure

The compound was prepared according to the procedure disclosed in Example 1 starting from lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (90 mg, 0.24 mmol) and pyrrolidine (54 mg, 0.76 mmol). Yield: 68 mg (66%).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-3ae39e5fed3d4543bd02dfd0844cf567
Source dataset
uspto-grants-2014_10
Patent number
US08859534B2

Reaction notes

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