HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Chloro-3-hydrazinopyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Chloro-3-hydrazinopyrazine | HCID 321430 | 90.9% |
Reaction Steps
2,3-dichloropyrazine (1000 g, 6.7 mol) and hydrazine monohydrate (700 g, 14 mol) were dissolved in absolute ethanol (2 L) and refluxed under N2 overnight. A crystalline precipitate formed, which was collected by filtration, washed with ethanol (1 L), and dried to afford the desired produced as a yellow solid (880 g, 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859550B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-6daf33a9fe334f0eb554ffecffc944f0 |
| Source note | uspto-grants-2014_10 |