Hydrazine hydrate (1:1) → 2-Chloro-3-hydrazinopyrazine

HRID 535705Notes

Reaction equation

HRID 535705 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(O)C>[Cl:1][C:2]1[C:7]([NH:10][NH2:11])=[N:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 785752,3-Dichloropyrazine

Product 1

HCID 3214302-Chloro-3-hydrazinopyrazineYield 90.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,3-dichloropyrazine (1000 g, 6.7 mol) and hydrazine monohydrate (700 g, 14 mol) were dissolved in absolute ethanol (2 L) and refluxed under N2 overnight. A crystalline precipitate formed, which was collected by filtration, washed with ethanol (1 L), and dried to afford the desired produced as a yellow solid (880 g, 90% yield).

Workup

  1. temperaturerefluxed under N2 overnight
  2. customA crystalline precipitate formed
  3. filtrationwhich was collected by filtration
  4. washwashed with ethanol (1 L)
  5. customdried
  6. customto afford the

Sources & evidence

ORD record
ord-6daf33a9fe334f0eb554ffecffc944f0
Source dataset
uspto-grants-2014_10
Patent number
US08859550B2

Reaction notes

Loading…