HRID53571

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10539870

未命名化合物

结构：CC(C)(C)[Si](OCc1ccc(CCCC=O)cc1)(c1ccccc1)c1ccccc1

HCID19694131

未命名化合物

HCID178418471

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](OCc1ccc(CCCC(O)CCCc2ccccc2)cc1)(c1ccccc1)c1ccccc1

HCID19694136

未命名化合物

收率 122.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The alcohol 173 was prepared from 2.12 g (5.0 mmol) of 172 and 9.0 mL (9 mmol) of 120 in 50 mL of THF as described for the synthesis of 121 in Example 1. Flash chromatography (elution with 10% ethyl acetate in hexane) gave 3.3 g of the alcohol 173. 1H NMR consistent with the product.

WORKUP

后处理

washFlash chromatography (elution with 10% ethyl acetate in hexane)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6cec43e01da4b7f9c141f242587d7b6
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05620971
来源说明: uspto-grants-1997_04

反应 SMILES

[Si:1]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][CH:29]=[O:30])=[CH:22][CH:21]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]1([CH2:37][CH2:38][CH2:39][Mg]Br)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C1(CCCC(O)CCCC2C=CC=CC=2)C=CC=CC=1>C1COCC1>[Si:1]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][CH:29]([OH:30])[CH2:39][CH2:38][CH2:37][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:22][CH:21]=1)([C:14]([CH3:16])([CH3:17])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1