反应详情

To a solution of tert-butyl(trans)-2-(3′-(trifluoromethyl)biphenyl-4-yl)cyclopropylcarbamate (5 g) in diethyl ether (50 mL) at 0° C., HCl in Diethyl ether (20 mL) was added and stirred for 1 h. After completion, the solvent was evaporated and residue was triturated with Et2O (20 mL) to give crude salt. The crude salt was dissolved in water (50 mL), basified with Na2CO3 solution, extracted with EtOAc (3×50 mL). The combined extracts were washed with water (50 mL), brine (50 mL), dried over anhydrous Na2SO4, filtered and evaporated to get crude (trans)-2-(3′-(trifluoromethyl)biphenyl-4-yl)cyclopropanamine (3.6 g, 98.09%) as a white solid

1. customAfter completion, the solvent was evaporated
2. customresidue was triturated with Et2O (20 mL)
3. customto give crude salt
4. extractionextracted with EtOAc (3×50 mL)
5. washThe combined extracts were washed with water (50 mL), brine (50 mL)
6. dry with materialdried over anhydrous Na2SO4
7. filtrationfiltered
8. customevaporated