Ethyl 3-amino-1H-pyrrole-2-carboxylate → 3-({[3-(2-Ethoxyethoxy)pyridin-2-yl]methyl}amino)-1H-pyrrole-2-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[C:8]([CH:13]=O)=[N:9][CH:10]=[CH:11][CH:12]=1)[CH3:2].[CH2:15]([O:17][C:18]([C:20]1[NH:21][CH:22]=[CH:23][C:24]=1[NH2:25])=[O:19])[CH3:16]>>[CH2:15]([O:17][C:18]([C:20]1[NH:21][CH:22]=[CH:23][C:24]=1[NH:25][CH2:13][C:8]1[C:7]([O:6][CH2:5][CH2:4][O:3][CH2:1][CH3:2])=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:19])[CH3:16]Participants
3
Procedure
The title compound (0.17 g, 73%) was prepared in accordance with general method A using 3-(2-ethoxyethoxy)pyridine-2-carbaldehyde (0.21 g, 1.08 mmol) and 3-amino-1H-pyrrole-2-carboxylic acid ethyl ester (0.11 g, 0.717 mmol).
Sources & evidence
- ORD record
- ord-702e81d9f4a24c2e837c09da13dd0db1
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08859568B2
Reaction notes
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