Hydrochloric Acid → HCID 57494510, compound

HRID 536142Notes

Reaction equation

[OH-].[Na+].C[O:4][C:5]([C:7]1[N:8]=[C:9]2[CH:25]=[CH:24][C:23]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=3[F:34])=[CH:22][N:10]2[C:11](=[O:21])[C:12]=1[O:13][Si](C(C)(C)C)(C)C)=[O:6].Cl>CO>[Cl:33][C:29]1[C:28]([F:34])=[C:27]([CH:32]=[CH:31][CH:30]=1)[CH2:26][C:23]1[CH:24]=[CH:25][C:9]2[N:10]([CH:22]=1)[C:11](=[O:21])[C:12]([OH:13])=[C:7]([C:5]([OH:6])=[O:4])[N:8]=2

Participants

Conditions

Temperature: 50 °C

Procedure

Aqueous sodium hydroxide (0.5 M, 1.1 mL) was added to a stirred solution of the product from Example 23.2 (22 mg, 0.046 mmol) in methanol (5 mL). The mixture was stirred at 50° C. for 24 h. Then aqueous hydrochloric acid (1.0 M) was added dropwise to adjust pH to 3˜4. The methanol was evaporated under reduced pressure and the resulting solid was collected by filtration and dried in vacuo to afford the desired compound as a brown solid (13 mg, 81%).

Workup

customThe methanol was evaporated under reduced pressure
filtrationthe resulting solid was collected by filtration
customdried in vacuo

Sources & evidence

ORD record: ord-e45ce6ba32a6493387c14d6e74d67569
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859563B2

Reaction notes

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