4-Bromobenzaldehyde → 4'-(Trifluoromethyl)-4-biphenylcarbaldehyde

HRID 536174Notes

Reaction equation

HRID 536174 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][CH:16]=1>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:15]2[CH:22]=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 707414-BromobenzaldehydeHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 27827124'-(Trifluoromethyl)-4-biphenylcarbaldehyde

Procedure

The title compound was prepared by a procedure similar to that described for D83 starting from [4-(trifluoromethyl)phenyl]boronic acid and 4-bromobenzaldehyde. LC-MS (ESI): m/z 251 [M+H]+; 3.63 min (ret time).

Workup

  1. custom3.63 min (ret time)

Sources & evidence

ORD record
ord-22e22617856e4df0952ce570dd09dee9
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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