Morpholine → 4-[(3-Chloropropyl)sulfonyl]morpholine

HRID 536225Notes

Reaction equation

HRID 536225 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[Cl:1][CH2:2][CH2:3][CH2:4][S:5]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)(=[O:7])=[O:6]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 154103-Chloropropanesulphonyl chloride

Product 1

HCID 2844074-[(3-Chloropropyl)sulfonyl]morpholine

Procedure

The procedure used for the preparation of Intermediate D was used to prepare the title compound from 3-chloropropanesulfonyl chloride and morpholine. High vacuum drying gave the title compound (1.3 g, 104%): 1H NMR (CDCl3) δ: 2.20-2.29 (2H, m), 3.02 (2H, dd), 3.20-3.23 (4H, m), 3.64 (2H, t), 3.68-3.72 (4H, m).

Sources & evidence

ORD record
ord-47c6a6ed53a64a11afce7f2f6206aa6b
Source dataset
uspto-grants-2014_10
Patent number
US08859572B2

Reaction notes

Loading…