Dimethylamine → 3-chloro-N,N-dimethylpropane-1-sulfonamide

HRID 536226Notes

Reaction equation

[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[CH3:9][NH:10][CH3:11]>>[Cl:1][CH2:2][CH2:3][CH2:4][S:5]([N:10]([CH3:11])[CH3:9])(=[O:7])=[O:6]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 154103-Chloropropanesulphonyl chloride

Product 1

HCID 100353283-chloro-N,N-dimethylpropane-1-sulfonamide

Procedure

The procedure used for the preparation of Intermediate D was used to prepare the title compound from 3-chloropropanesulfonyl chloride and dimethylamine. High vacuum drying gave the title compound (2.1 g, 100%): 1H NMR (DMSO-d6) δ: 2.06-2.11 (2H, m), 2.75 (6H, s), 3.10-3.15 (2H, m), 3.72 (2H, t).

Sources & evidence

ORD record: ord-6752174e0ffa469aa497eeb1583e1dba
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859572B2

Reaction notes

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