Dimethyl-1,3-thiazole-5-carboxylic acid → HCID 178487303, compound

HRID 536260Notes

Reaction equation

HRID 536260 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]2[C:8]3[N:9]([CH2:15][CH2:16][N:17]=3)[C:10]([NH2:14])=[N:11][C:12]=2[CH:13]=1.[CH3:18][C:19]1[S:20][C:21]([C:25](O)=[O:26])=[C:22]([CH3:24])[N:23]=1>>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]2[C:8]3[N:9]([CH2:15][CH2:16][N:17]=3)[C:10]([NH:14][C:25]([C:21]3[S:20][C:19]([CH3:18])=[N:23][C:22]=3[CH3:24])=[O:26])=[N:11][C:12]=2[CH:13]=1

Participants

3

Reactant 2

HCID 736488Dimethyl-1,3-thiazole-5-carboxylic acidHCID 1784195958-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine;hydrobromide2×

Product 1

HCID 178487303HCID 178487303, compound

Procedure

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 8-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine hydrobromide (Intermediate I, Step 3) and 2,4-dimethyl-1,3-thiazole-5-carboxylic acid as white solid (4.26 g, 77%): HPLC MS RT=2.05 min, MH+=356.1;

Workup

  1. customThe procedure used for the preparation of Example 16, Step 2

Sources & evidence

ORD record
ord-b04f1ac55cff4396b5e801b14b099c4d
Source dataset
uspto-grants-2014_10
Patent number
US08859572B2

Reaction notes

Loading…