4-[(3-Chloropropyl)sulfonyl]morpholine → HCID 178508203, compound

HRID 536262Notes

Reaction equation

HRID 536262 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]2[C:8]3[N:9]([CH2:15][CH2:16][N:17]=3)[C:10]([NH2:14])=[N:11][C:12]=2[CH:13]=1.ClC[CH2:20][CH2:21][S:22]([N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)(=[O:24])=[O:23]>>[N:25]1([S:22]([CH2:21][CH2:20][CH2:2][O:3][C:4]2[CH:5]=[CH:6][C:7]3[C:8]4[N:9]([CH2:15][CH2:16][N:17]=4)[C:10]([NH2:14])=[N:11][C:12]=3[CH:13]=2)(=[O:24])=[O:23])[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 2844074-[(3-Chloropropyl)sulfonyl]morpholine2×HCID 1784195958-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine;hydrobromide2×

Product 1

HCID 178508203HCID 178508203, compound

Procedure

The procedure used for the preparation of Example 24, Step 2 was used to prepare the title compound from 5-amino-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol (Intermediate I) and 4-[(3-chloropropyl)sulfonyl]morpholine (Intermediate E). Yield 190 mg (61%). Rf=0.68 in 10% MeOH/CH2Cl2, HPLC MS RT=1.13 min, MH+=394.4.

Workup

  1. customThe procedure used for the preparation of Example 24, Step 2

Sources & evidence

ORD record
ord-c3df135775ee41428495ce412037b458
Source dataset
uspto-grants-2014_10
Patent number
US08859572B2

Reaction notes

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