4-Toluenesulfonyl chloride → HCID 178493912, compound

HRID 536271Notes

Reaction equation

HRID 536271 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[C:12]3[N:13]([CH2:29][CH2:30][N:31]=3)[C:14]([NH:20][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=3)=[N:15][C:16]=2[C:17]=1[O:18][CH3:19].[CH3:32][C:33]1[CH:38]=[CH:37][C:36]([S:39](Cl)(=[O:41])=[O:40])=[CH:35][CH:34]=1>>[CH3:19][O:18][C:17]1[C:16]2[N:15]=[C:14]([NH:20][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=3)[N:13]3[CH2:29][CH2:30][N:31]=[C:12]3[C:11]=2[CH:10]=[CH:9][C:8]=1[O:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][NH:1][S:39]([C:36]1[CH:37]=[CH:38][C:33]([CH3:32])=[CH:34][CH:35]=1)(=[O:41])=[O:40]

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 178493908HCID 178493908, compound

Product 1

HCID 178493912HCID 178493912, compound

Procedure

The procedure used for the preparation of Example 31, Step 5 was used to prepare the title compound from N-{8-[2-(2-aminoethoxy)-ethoxy]-7-methoxy-2,3-dihydro-imidazo[1,2-c]quinazolin-5-yl}-nicotinamide (Example 31, Step 4) and (4-methylphenyl)sulfonyl chloride. HPLC MS RT=2.35 min, MH+=579.5.

Workup

  1. customThe procedure used for the preparation of Example 31, Step 5

Sources & evidence

ORD record
ord-7fef028e9dab4892b28d790b671bfe5b
Source dataset
uspto-grants-2014_10
Patent number
US08859572B2

Reaction notes

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