Hydrochloric Acid → 4-((S)-2-Methyl-pyrrolidin-1-yl)piperidine

HRID 536303Notes

Reaction equation

HRID 536303 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][CH2:16][C@@H:15]2[CH3:19])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH3:19][C@H:15]1[CH2:16][CH2:17][CH2:18][N:14]1[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58468064BOC-4-((S)-2-Methyl-pyrrolidin-1-yl)piperidine

Product 1

HCID 584680514-((S)-2-Methyl-pyrrolidin-1-yl)piperidineYield 165.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a chilled solution of Intermediate (viii), 4-((S)-2-methyl-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester, (2.43 g, 9.05 mmol) in 1,4-dioxane (9 mL) at 0° C. was added 4N HCl in dioxane (6 mL) and allowed to stir for 20 h at ambient temperature. The reaction mixture was concentrated to afford an oil which was dried under high vacuum to afford 2.52 g of the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto afford an oil which
  3. customwas dried under high vacuum

Sources & evidence

ORD record
ord-171157d2e5034a3494c070c57d29a782
Source dataset
uspto-grants-2014_10
Patent number
US08859588B2

Reaction notes

Loading…