反应详情

A solution of 76.0 mg (0.19 mmol) of the imino derivative from Example 23 in 5.0 mL of concentrated hydrochloric acid was heated at reflux for 3 days, and the solvent was then removed by evaporation. The residue was triturated with water, filtered, and dried to afford 6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, as a hydrate;

1. temperatureat reflux for 3 days
2. customthe solvent was then removed by evaporation
3. customThe residue was triturated with water
4. filtrationfiltered
5. customdried