HCID 178430393, compound → HCID 178481371, compound

HRID 53631Notes

Reaction equation

HRID 53631 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:10](=N)[CH:11]([CH3:20])[C:12]2[N:17]=[C:16]([OH:18])[N:15]=CC=2N=1>Cl>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[C:16](=[O:18])[N:17]([CH3:12])[C:12]2[N:17]=[C:16]([OH:18])[N:15]=[CH:20][C:11]=2[CH:10]=1

Participants

3

Reactant 1

HCID 178430393HCID 178430393, compound

Product 1

HCID 178481371HCID 178481371, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 76.0 mg (0.19 mmol) of the imino derivative from Example 23 in 5.0 mL of concentrated hydrochloric acid was heated at reflux for 3 days, and the solvent was then removed by evaporation. The residue was triturated with water, filtered, and dried to afford 6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, as a hydrate;

Workup

  1. temperatureat reflux for 3 days
  2. customthe solvent was then removed by evaporation
  3. customThe residue was triturated with water
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-82e717d313a2453689a41b2dadbdda95
Source dataset
uspto-grants-1997_04
Patent number
US05620981

Reaction notes

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