Acetonitrile → HCID 178507819, compound

HRID 53638Notes

Reaction equation

HRID 53638 reaction equation
[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5](C(O)=O)=[CH:4][C:3]=1[Cl:15].[C:16](#[N:18])[CH3:17]>>[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[CH:5]=[CH:4][C:3]=1[Cl:15].[NH:18]1[C-:16]=[CH:17][N:1]=[CH:2]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 117759978-Amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

Product 1

HCID 178507819HCID 178507819, compound

Procedure

To a stirred solution of 8-amino-7-chloro-1,4-benzodioxan-5-carboxylic acid (prepared from the corresponding 7-H acid (prepared as in GB 1571278) by chlorination of the protected form) (1.10 g) in acetonitrile was added bis-carbonyldiimidazole (0.77 g). The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed under reduced pressure to afford crude 8- amino-7-chloro-1,4-benzodioxan-5-imidazolide.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-e0498bcb86054a64809631318e4661f5
Source dataset
uspto-grants-1997_04
Patent number
US05620992

Reaction notes

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