Ammonia → HCID 71285801, compound

HRID 536489Notes

Reaction equation

HRID 536489 reaction equation
C([O:3][C:4]([C:6]1[N:10]2[CH:11]=[CH:12][CH:13]=[N:14][C:9]2=[C:8]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[N:7]=1)=O)C.[NH3:23]>CO>[F:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][C:8]1[N:7]=[C:6]([C:4]([NH2:23])=[O:3])[N:10]2[CH:11]=[CH:12][CH:13]=[N:14][C:9]=12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 59177872HCID 59177872, compound

Product 1

HCID 71285801HCID 71285801, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
150 °C

Procedure

8.200 g (27.40 mmol) of ethyl-8-(2-fluorobenzyl)imidazo[1,5-a]pyrimidine-6-carboxylate was distributed in 8 microwave vessels. Each vessel was charged with 10 ml of 7N solution of ammonia in methanol and stirred for 80 min at 150° C. in the microwave. After cooling, the contents of the vessels were combined, the resultant precipitate was filtered with suction, washed with a little methanol and dried under high vacuum. 8.42 g (quant.) of the target compound was obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resultant precipitate was filtered with suction
  3. washwashed with a little methanol
  4. customdried under high vacuum
  5. custom8.42 g (quant.) of the target compound was obtained

Sources & evidence

ORD record
ord-dce551c10d0d442ea9c3662092311dd9
Source dataset
uspto-grants-2014_10
Patent number
US08859569B2

Reaction notes

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