Ammonia → HCID 71285801, compound

Participants

Reaction Conditions

Reaction Steps

8.200 g (27.40 mmol) of ethyl-8-(2-fluorobenzyl)imidazo[1,5-a]pyrimidine-6-carboxylate was distributed in 8 microwave vessels. Each vessel was charged with 10 ml of 7N solution of ammonia in methanol and stirred for 80 min at 150° C. in the microwave. After cooling, the contents of the vessels were combined, the resultant precipitate was filtered with suction, washed with a little methanol and dried under high vacuum. 8.42 g (quant.) of the target compound was obtained.

Provenance & Evidence