反应详情

温度

85 °C

3.770 g (14.08 mmol) of diiodomethane and 411 mg (3.51 mmol) of isopentyl nitrite were added to 70 mg (0.17 mmol) of 4-amino-2-[1-(2-fluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one. The mixture was stirred for 8 h at 85° C. After cooling, it was diluted with acetonitrile and the mixture was purified by preparative HPLC (eluent: acetonitrile/water, gradient 30:70→95:5). 35 mg (24% of theor.) of the target compound was obtained.

1. temperatureAfter cooling
2. customthe mixture was purified by preparative HPLC (eluent: acetonitrile/water, gradient 30:70→95:5)
3. custom35 mg (24% of theor.) of the target compound was obtained