反应详情

温度

150 °C

40 mg (0.07 mmol) of 2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (example 33A) was dissolved in 1 ml of absolute NMP and 334 mg (2.96 mmol) of 3,3,3-trifluoropropan-1-amine was added. The mixture was heated in the microwave for 2 h at 150° C. and 1 h at 150° C. The reaction solution was filtered and purified by preparative HPLC (eluent: acetonitrile/water with 0.1% hydrochloric acid, gradient 20:80→100:0). 27 mg (purity 93%, 70% of theor.) of the target compound was obtained.

1. filtrationThe reaction solution was filtered
2. custompurified by preparative HPLC (eluent: acetonitrile/water with 0.1% hydrochloric acid, gradient 20:80→100:0)
3. custom27 mg (purity 93%, 70% of theor.) of the target compound was obtained