Hydrochloric Acid → HCID 58460122, compound

Participants

Reaction Steps

An amount of 21.43 g (67.9 mmol) of the compound from Example 16A was admixed with 91 ml of a 3 N sodium hydroxide solution and heated under reflux overnight. After cooling to RT, the mixture was adjusted to a pH of 1 by slow addition of approximately 20% strength hydrochloric acid. The precipitated solid was isolated by filtration, washed with water and dried at 60° C. under reduced pressure. This gave 17.55 g of the title compound in approximately 88% purity (90% of theory).

Provenance & Evidence