Hydrochloric Acid → HCID 58460122, compound

HRID 536539Notes

Reaction equation

HRID 536539 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][NH:11][C:12]([NH:14][CH2:15][C:16]([O:18]CC)=[O:17])=[O:13])=O)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:14]([CH2:15][C:16]([OH:18])=[O:17])[C:12](=[O:13])[NH:11][N:10]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59536829HCID 59536829, compound

Product 1

HCID 58460122HCID 58460122, compound

Procedure

An amount of 21.43 g (67.9 mmol) of the compound from Example 16A was admixed with 91 ml of a 3 N sodium hydroxide solution and heated under reflux overnight. After cooling to RT, the mixture was adjusted to a pH of 1 by slow addition of approximately 20% strength hydrochloric acid. The precipitated solid was isolated by filtration, washed with water and dried at 60° C. under reduced pressure. This gave 17.55 g of the title compound in approximately 88% purity (90% of theory).

Workup

  1. temperatureheated
  2. temperatureunder reflux overnight
  3. customThe precipitated solid was isolated by filtration
  4. washwashed with water
  5. customdried at 60° C. under reduced pressure

Sources & evidence

ORD record
ord-00f6ff4b4f85419d9c584a92bf9d2c40
Source dataset
uspto-grants-2014_10
Patent number
US08859601B2

Reaction notes

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