HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(bromomethyl)benzoate → Methyl 3-{[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(bromomethyl)benzoate | HCID 517981 | — |
| Reactant | Methyl 4-{[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoate | HCID 58460117 | — |
| Reactant | 5-(4-Chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 58460118 | — |
| Product | Methyl 3-{[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoate | HCID 58460127 | — |
Reaction Steps
In the same way as for the compound from Example 24A, 267 mg (0.87 mmol) of the compound from Example 19A were reacted with 199 mg (0.87 mmol) of methyl 3-(bromomethyl)benzoate. This gave 302 mg (76% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859601B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-5951548bd4f449248b3f3f472093d770 |
| Source note | uspto-grants-2014_10 |