反应详情

温度

80 °C

An amount of 280 mg (0.61 mmol) of the compound from Example 24A was dissolved in 4 ml of a 1:1 mixture of methanol and THF and admixed with 0.61 ml of 2 N sodium hydroxide solution. It was stirred at 80° C. for 1 h. For working out, it was admixed with 5 ml of water and extracted with 5 ml of ethyl acetate. The aqueous phase was acidified to a pH of 1 using 1 N hydrochloric acid and extracted with twice 5 ml of ethyl acetate. The combined organic phases were dried over sodium sulphate and freed from the solvent on a rotary evaporator. This gave 275 mg (100% of theory) of the target compound.

1. extractionextracted with 5 ml of ethyl acetate
2. extractionextracted with twice 5 ml of ethyl acetate
3. dry with materialThe combined organic phases were dried over sodium sulphate
4. customfreed from the solvent on a rotary evaporator