Hydroxylamine → HCID 178421475, compound

HRID 536687Notes

Reaction equation

HRID 536687 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:19][CH2:18][C:17]4([CH3:23])[C:20]([CH3:22])([CH3:21])[CH:13]3[CH2:14][C:15]3[CH:27]=[C:26]([C:28]#[N:29])[CH:25]=[CH:24][C:16]=34)=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH2:30][OH:31]>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:19][CH2:18][C:17]4([CH3:23])[C:20]([CH3:22])([CH3:21])[CH:13]3[CH2:14][C:15]3[CH:27]=[C:26]([C:28]([NH:30][OH:31])=[NH:29])[CH:25]=[CH:24][C:16]=34)=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 178421474HCID 178421474, compound

Product 1

HCID 178421475HCID 178421475, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-(1H-benzoimidazole-5-carbonyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-9-carbonitrile (0.30 g) and hydroxylamine (50% in water, 0.5 ml) in ethanol (5 mL) is stirred at reflux temperature for 2 h. After cooling to room temperature, the mixture is concentrated under reduced pressure to give the title compound as a white foam-like solid.

Workup

  1. temperatureat reflux temperature for 2 h
  2. concentrationthe mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-e9405598c36449f6ae0458d18279b92b
Source dataset
uspto-grants-2014_10
Patent number
US08859580B2

Reaction notes

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