Tetrahydro-4H-pyran-4-one → HCID 178424654, compound

HRID 536954Notes

Reaction equation

HRID 536954 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH2:13][CH2:12][C:11]([CH3:15])([CH3:14])[CH2:10][CH:9]=2)[C:3]=1[NH:16][C:17]([C:19]1[NH:20][CH:21]=[C:22]([C:24]#[N:25])[N:23]=1)=[O:18].[O:26]1[CH2:31][CH2:30][C:29](=[O:32])[CH2:28][CH2:27]1>>[CH3:14][C:11]1([CH3:15])[CH2:12][CH2:13][C:8]([C:4]2[C:3]([NH:16][C:17]([C:19]3[NH:20][CH:21]=[C:22]([C:24]#[N:25])[N:23]=3)=[O:18])=[CH:2][CH:7]=[C:6]([C:29]3([OH:32])[CH2:30][CH2:31][O:26][CH2:27][CH2:28]3)[N:5]=2)=[CH:9][CH2:10]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 178424655HCID 178424655, compound

Product 1

HCID 178424654HCID 178424654, compound

Procedure

The title compound was prepared as described in Example 1 step (h) using 4-cyano-1H-imidazole-2-carboxylic acid [4-bromo-2-(4,4-dimethyl-cyclohex-1-enyl)-pyridine-3-yl]-amide (as prepared in the Example 32 steps (d)) and tetrahydropyran-4-one. Mass spectrum (ESI, m/z): Calcd. for C25H27N5O3, 422.2 (M+H). found 422.2.

Sources & evidence

ORD record
ord-1380ec2b07954ae9a8c22e24aa7f802c
Source dataset
uspto-grants-2014_10
Patent number
US08859602B2

Reaction notes

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