反应详情

A solution of 4-(4-nitro-phenyl)-1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbonitrile (as prepared in the previous step) in ethanol and water is treated with NaBO3 (Synthetic Communications, 20(4), 563-71, (1990)). The mixture is diluted with EtOAc and washed with water. The organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.

1. washwashed with water
2. dry with materialThe organic layer is dried (MgSO4)
3. concentrationconcentrated in vacuo
4. customThe residue is purified by silica gel chromatography with the appropriate solvent