Tetrahydro-4H-pyran-4-one → HCID 178424654, compound

HRID 536964Notes

Reaction equation

HRID 536964 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]2[CH2:13][CH2:12][C:11]([CH3:15])([CH3:14])[CH2:10][CH:9]=2)[C:5]([NH:16][C:17]([C:19]2[NH:20][C:21]([C:24]#[N:25])=[CH:22][N:23]=2)=[O:18])=[CH:4][CH:3]=1.[O:26]1[CH2:31][CH2:30][C:29](=[O:32])[CH2:28][CH2:27]1>>[CH3:14][C:11]1([CH3:15])[CH2:12][CH2:13][C:8]([C:6]2[C:5]([NH:16][C:17]([C:19]3[NH:23][CH:22]=[C:21]([C:24]#[N:25])[N:20]=3)=[O:18])=[CH:4][CH:3]=[C:2]([C:29]3([OH:32])[CH2:30][CH2:31][O:26][CH2:27][CH2:28]3)[N:7]=2)=[CH:9][CH2:10]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 58993772HCID 58993772, compound

Product 1

HCID 178424654HCID 178424654, compound

Procedure

The title compound was prepared from 5-cyano-1H-imidazole-2-carboxylic acid [6-bromo-2-(4,4-dimethyl-cyclohex-1-enyl)-pyridin-3-yl]-amide (as prepared in Example 32, step (d)) and tetrahydro-pyran-4-one according to the procedure in Example 1, step (h).

Sources & evidence

ORD record
ord-b93b965ec1934c558f8cdaaa7b5ae831
Source dataset
uspto-grants-2014_10
Patent number
US08859602B2

Reaction notes

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