1-Methylpiperazine → HCID 178480606, compound

HRID 536965Notes

Reaction equation

[CH3:1][C:2]1([CH3:31])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][CH:19]=[C:20]([C:22]#[N:23])[N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24]3(O)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[N:9]=2)=[CH:4][CH2:3]1.[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[CH3:1][C:2]1([CH3:31])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][CH:19]=[C:20]([C:22]#[N:23])[N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24]3([N:36]4[CH2:37][CH2:38][N:33]([CH3:32])[CH2:34][CH2:35]4)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[N:9]=2)=[CH:4][CH2:3]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 178424654HCID 178424654, compound

Product 1

HCID 178480606HCID 178480606, compound

Procedure

The title compound is prepared from 4-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-6-(4-hydroxy-tetrahydro-pyran-4-yl)-pyridin-3-yl]-amide (as prepared in the previous step) and N-methylpiperazine according to the procedure in Example 4.

Sources & evidence

ORD record: ord-2caf665b972e4b6b8f07bcd910bac05b
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859602B2

Reaction notes

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