Pyrrolidine → HCID 178428187, compound

HRID 536968Notes

Reaction equation

HRID 536968 reaction equation
[CH:1]([C:3]1([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:18]3[NH:19][CH:20]=[C:21]([C:23]#[N:24])[N:22]=3)=[O:17])=[C:11]([N:25]3[CH2:30][CH2:29][CH:28]([CH3:31])[CH2:27][CH2:26]3)[CH:10]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)=O.[NH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH3:31][CH:28]1[CH2:27][CH2:26][N:25]([C:11]2[CH:10]=[C:9]([C:3]3([CH2:1][N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)[CH2:4][CH2:5][O:6][CH2:7][CH2:8]3)[CH:14]=[CH:13][C:12]=2[NH:15][C:16]([C:18]2[NH:19][CH:20]=[C:21]([C:23]#[N:24])[N:22]=2)=[O:17])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 178428188HCID 178428188, compound

Product 1

HCID 178428187HCID 178428187, compound

Procedure

The title compound is prepared by the procedure of Example 26, step (b) using 4-cyano-1H-imidazole-2-carboxylic acid [4-(4-formyl-tetrahydro-pyran-4-yl)-2-(4-methyl-piperidin-1-yl)-phenyl]-amide (as prepared in the previous step) and pyrrolidine.

Sources & evidence

ORD record
ord-128c23dc35064a5fb8637f50d39aa4fd
Source dataset
uspto-grants-2014_10
Patent number
US08859602B2

Reaction notes

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