Lithium Hydroxide → 5-Methoxyquinoline-3-carboxylic acid

HRID 537158Notes

Reaction equation

HRID 537158 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([C:13]([O:15]C)=[O:14])[CH:7]=[N:8]2.[OH-].[Li+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[N:8]2

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 57440609HCID 57440609, compound

Product 1

HCID 231597415-Methoxyquinoline-3-carboxylic acid

Procedure

Methyl 5-methoxyquinoline-3-carboxylate (Organic and Biomolecular Chemistry, 7(12), 2612-2618; 2009) was saponified using aqueous lithium hydroxide. +ESI (M+H) 203.9; 1H NMR (400 MHz, DMSO-d6, δ): 9.30 (d, 1H), 9.03 (d, 1H), 7.84-7.80 (m, 1H), 7.66 (d, 1H), 7.15 (d, 1H), 4.04 (s, 3H).

Sources & evidence

ORD record
ord-86c8792d3b1c41e6bf0af408018e9565
Source dataset
uspto-grants-2014_10
Patent number
US08859773B2

Reaction notes

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