HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Methyl 2,2-Dibenzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | Methyl 3-[4-(4-Chlorophenyl)-4-fluoropiperidin-1-yl]propionate | HCID 67462732 | — |
| Product | Methyl 2,2-Dibenzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate | HCID 67468586 | 38% |
Reaction Steps
This compound was prepared from methyl 3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate and 2.5 equivalents of both lithium hexamethyldisilazide and benzyl bromide as described in Step 2 of Example 4 in 38% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-03cfaf26f42f40ce838df5ba7d75bb59 |
| Source note | uspto-grants-2014_10 |