Methyl Acrylate → Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoropiperidin-1-yl]propionate

HRID 537212Notes

Reaction equation

HRID 537212 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:22])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:23]([O:27][CH3:28])(=[O:26])[CH:24]=[CH2:25]>>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:22])[CH2:17][CH2:18][N:19]([CH2:25][CH2:24][C:23]([O:27][CH3:28])=[O:26])[CH2:20][CH2:21]2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 7294Methyl AcrylateHCID 674607714-(3-benzyloxyphenyl)-4-fluoropiperidine Hydrochloride

Product 1

HCID 67466200Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoropiperidin-1-yl]propionateYield 86%

Procedure

This compound was prepared from 4-(3-benzyloxyphenyl)-4-fluoropiperidine hydrochloride and methyl acrylate as described in Step 1 of Example 4 in 86% yield.

Sources & evidence

ORD record
ord-4b28106b4eca49fdaf2c7547eb412077
Source dataset
uspto-grants-2014_10
Patent number
US08859777B2

Reaction notes

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