HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Benzyloxyphenyl)-4-fluoro-1-(3-phenylpropyl)piperidine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3-Bromopropyl)benzene | HCID 12503 | — |
| Reactant | 4-(3-benzyloxyphenyl)-4-fluoropiperidine Hydrochloride | HCID 67460771 | — |
| Product | 4-(3-Benzyloxyphenyl)-4-fluoro-1-(3-phenylpropyl)piperidine Hydrochloride | HCID 67464847 | — |
Reaction Steps
This material was prepared by the alkylation of 4-(3-benzyloxyphenyl)-4-fluoropiperidine hydrochloride with 1-bromo-3-phenylpropane and subsequent salt formation with methanolic hydrogen chloride as described in Step 3 of Example 1 in 43% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-05dd8fd18a5e4963b050ca0853ea7eef |
| Source note | uspto-grants-2014_10 |