Hydrochloric Acid → 4-(3-Benzyloxyphenyl)-4-fluoro-1-(3-phenylpropyl)piperidine Hydrochloride

HRID 537215Notes

Reaction equation

HRID 537215 reaction equation
[ClH:1].[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:22])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.Cl>>[ClH:1].[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:22])[CH2:17][CH2:18][N:19]([CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:20][CH2:21]2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 12503(3-Bromopropyl)benzeneHCID 674607714-(3-benzyloxyphenyl)-4-fluoropiperidine Hydrochloride

Product 1

HCID 674648474-(3-Benzyloxyphenyl)-4-fluoro-1-(3-phenylpropyl)piperidine Hydrochloride

Procedure

This material was prepared by the alkylation of 4-(3-benzyloxyphenyl)-4-fluoropiperidine hydrochloride with 1-bromo-3-phenylpropane and subsequent salt formation with methanolic hydrogen chloride as described in Step 3 of Example 1 in 43% overall yield.

Sources & evidence

ORD record
ord-05dd8fd18a5e4963b050ca0853ea7eef
Source dataset
uspto-grants-2014_10
Patent number
US08859777B2

Reaction notes

Loading…