Methyl Acrylate → Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]propionate

HRID 537220노트

반응식

HRID 537220 반응식
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:23])[CH2:21][CH2:20][NH:19][CH2:18][CH:17]2[CH3:22])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:24]([O:28][CH3:29])(=[O:27])[CH:25]=[CH2:26]>>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:23])[CH2:21][CH2:20][N:19]([CH2:26][CH2:25][C:24]([O:28][CH3:29])=[O:27])[CH2:18][CH:17]2[CH3:22])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 7294Methyl AcrylateHCID 674631514-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidine hydrochloride

생성물 1

HCID 67464042Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]propionate수율 81%

실험 절차

This compound was prepared from 4-(3-benzyloxyphenyl)-4-fluoro-3-methylpiperidine hydrochloride and methyl acrylate as described in Step 1 of Example 4 in 81% yield.

출처 및 근거

ORD 기록
ord-474fc9bc1f19430799ee98378aeac3f7
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859777B2

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