Methanesulfonyl chloride → HCID 67466702, compound

HRID 537223Notes

Reaction equation

HRID 537223 reaction equation
Cl.Cl.[NH2:3][C:4]1[CH:5]=[C:6]([C:10]2([F:25])[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1.[CH3:26][S:27]([Cl:30])(=[O:29])=[O:28].C(N(C(C)C)CC)(C)C>>[ClH:30].[F:25][C:10]1([C:6]2[CH:5]=[C:4]([NH:3][S:27]([CH3:26])(=[O:29])=[O:28])[CH:9]=[CH:8][CH:7]=2)[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 67467476HCID 67467476, compound

Product 1

HCID 67466702HCID 67466702, compoundYield 64%

Procedure

The title compound was prepared from the reaction of 4-(3-aminophenyl)-1-(2-phenoxyethyl) 4-fluoropiperidine dihydrochloride with methanesulfonyl chloride in the presence of excess diisopropylethylamine as described in Example 17. The desired material was obtained in 64% yield as an off-white solid.

Sources & evidence

ORD record
ord-984f6d60a2474015b47b1742f2402f1f
Source dataset
uspto-grants-2014_10
Patent number
US08859777B2

Reaction notes

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