HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67460895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxylate | HCID 49760242 | — |
| Product | HCID 67460895 | HCID 67460895 | 76% |
Reaction Steps
This material was prepared from the reaction of tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxylate with diethylaminosulfur trifluoride and deprotection of the crude product using methanolic hydrogen chloride as described in Step 2 of Example 1 to afford 4-(3-methoxyphenyl)-4-fluoropiperidine hydrochloride in 76% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859777B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a3a020cdc4584c9a8507d627903e56e9 |
| Source note | uspto-grants-2014_10 |