Hydrochloric Acid → HCID 67460895, compound

HRID 537228Notes

Reaction equation

HRID 537228 reaction equation
O[C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.C(N(S(F)(F)[F:29])CC)C.[ClH:32]>>[ClH:32].[CH3:22][O:21][C:17]1[CH:16]=[C:15]([C:2]2([F:29])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]2)[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 123472(Diethylamino)sulfur trifluorideHCID 49760242tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxylate

Product 1

HCID 67460895HCID 67460895, compoundYield 76%

Procedure

This material was prepared from the reaction of tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxylate with diethylaminosulfur trifluoride and deprotection of the crude product using methanolic hydrogen chloride as described in Step 2 of Example 1 to afford 4-(3-methoxyphenyl)-4-fluoropiperidine hydrochloride in 76% yield.

Sources & evidence

ORD record
ord-a3a020cdc4584c9a8507d627903e56e9
Source dataset
uspto-grants-2014_10
Patent number
US08859777B2

Reaction notes

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